SIDRA

Sample Set Annotation Tool

Clear Search Hide Filters
You are not logged in. | Log in

CD4+ T Cell Decline is Predicted by Differential Expression of Genes in HIV seropositive patients - GSE10924

In Progress
Clinical

CD4+ T Cell Decline is Predicted by Differential Expression of Genes in HIV seropositive patients - GSE10924

Purpose

Patterns of expressed genes examined in cryopreserved peripheral blood mononuclear cells (PBMCs) of seropositive persons electing to stop antiretroviral therapy in the AIDS Clinical Trials Group Study A 5170, were scrutinized to identify markers capable of predicting the likelihood of CD4+ T cell depletion after cessation of ART.

Two cohorts were matched for clinical characteristics in a study of the effects of therapy interruption (TI) in ART-treated patients with immunological preservation. Disease progression was determined by CD4+ T cell count decline 24 weeks after TI.Gene Set Enrichment Analysis (GSEA) identified a set of genes in the Ras signaling pathway, associated with the downregulation of apoptosis, as significantly upregulated in the good outcome group at cessation of ART.

Hypothesis

--

Experimental Design

There are 96 samples in this study. 24 patients with good outcome results and 24 matched patients with poor outcome results. Each patient has two time points: week0 and week 24

Experimental Variables

--

Controls

--

Methods

--

Additional Information

--

Microarray
Affymetrix Affymetrix Human HG-Focus v1
96 Samples Loaded: 96
Human (Homo sapiens)
PBMC
HIV
Sample Set Spreadsheet
Please log in in order to upload files.
Samples Preview
Sample ID !Sample_title This sample is from Poor outcome group at week 0 This sample is from Poor outcome group at week 24 This sample is from Poor outcome group at week 18 This sample is from Good outcome group at week 24
GSM276899 Patient 101141 at week 0
GSM276900 Patient 101141 at week 24 True
GSM276901 Patient 101774 at week 0
GSM276902 Patient 101774 at week 24 True
GSM276903 Patient 102128 at week 0

Upload Files

Please log in in order to upload files.

Browse Files

File
sampleset4000038_sampleannotations.csv
Sample Set Spreadsheet
Log2 Transformed
Raw Signal
  •   |  View in GXB »
Clinical Datasource
Links
http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE10924
http://www.ncbi.nlm.nih.gov/pubmed/18724805

Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID !Sample Title This sample is from Poor outcome group at week 0 This sample is from Poor outcome group at week 24 This sample is from Poor outcome group at week 18 This sample is from Good outcome group at week 24 This sample is from Poor outcome group at week 12 This sample is from Good outcome group at week 0 This sample is from Poor outcome group at week 32 Outcome Week
GSM276899
Patient 101141 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276900
Patient 101141 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276901
Patient 101774 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276902
Patient 101774 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276903
Patient 102128 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276904
Patient 102128 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276905
Patient 108036 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276906
Patient 108036 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276907
Patient 108037 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276908
Patient 108037 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276909
Patient 121522 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276910
Patient 121522 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276911
Patient 220946 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276912
Patient 220946 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276913
Patient 272221 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276914
Patient 272221 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276915
Patient 272384 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276916
Patient 272384 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276917
Patient 272385 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276918
Patient 272385 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276919
Patient 272386 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276920
Patient 272386 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276921
Patient 321183 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276922
Patient 321183 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276923
Patient 373698 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276924
Patient 373698 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276925
Patient 373713 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276926
Patient 373713 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276927
Patient 373722 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276928
Patient 373722 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276929
Patient 373734 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276930
Patient 373734 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276931
Patient 43379 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276932
Patient 43379 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276933
Patient 44624 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276934
Patient 44624 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276935
Patient 51284 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276936
Patient 51284 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276937
Patient 520819 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276938
Patient 520819 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276939
Patient 70466 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276940
Patient 70466 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276941
Patient 72701 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276942
Patient 72701 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276943
Patient 83221 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276944
Patient 83221 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276945
Patient 83241 at week 0
 
 
 
 
 
True
 
Good outcome_week 0
GSM276946
Patient 83241 at week 24
 
 
 
True
 
 
 
Good outcome_week 24
GSM276947
Patient 108041 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276948
Patient 108041 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276949
Patient 108046 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276950
Patient 108046 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276951
Patient 108053 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276952
Patient 108053 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276953
Patient 141612 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276954
Patient 141612 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276955
Patient 220963 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276956
Patient 220963 at week 12
 
 
 
 
True
 
 
Poor outcome_week 12
GSM276957
Patient 281266 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276958
Patient 281266 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276959
Patient 281286 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276960
Patient 281286 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276961
Patient 291214 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276962
Patient 291214 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276963
Patient 321399 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276964
Patient 321399 at week 18
 
 
True
 
 
 
 
Poor outcome_week 18
GSM276965
Patient 373679 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276966
Patient 373679 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276967
Patient 373700 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276968
Patient 373700 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276969
Patient 373707 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276970
Patient 373707 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276971
Patient 373718 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276972
Patient 373718 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276973
Patient 373732 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276974
Patient 373732 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276975
Patient 51270 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276976
Patient 51270 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276977
Patient 621409 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276978
Patient 621409 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276979
Patient 630694 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276980
Patient 630694 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276981
Patient 72708 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276982
Patient 72708 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276983
Patient 72710 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276984
Patient 72710 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276985
Patient 72719 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276986
Patient 72719 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276987
Patient 83224 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276988
Patient 83224 at week 32
 
 
 
 
 
 
True
Poor outcome_week 32
GSM276989
Patient 83225 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276990
Patient 83225 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276991
Patient 83227 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276992
Patient 83227 at week 24
 
True
 
 
 
 
 
Poor outcome_week 24
GSM276993
Patient 83242 at week 0
True
 
 
 
 
 
 
Poor outcome_week 0
GSM276994
Patient 83242 at week 12
 
 
 
 
True
 
 
Poor outcome_week 12

Group Sets View in Gene Expression Browser

Name  
All Samples Default  View
In order to make new Group Sets or change settings, please log in.

Module Analysis

Group Set  
All Samples

Send a Bug Report

Your bug report has been sent!