Sample Set Annotation Tool: Genome wide mRNA expression correlates of viral control in CD4+T cells from HIV-1 infected individuals

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

There is great interindividual variability in HIV-1 viral set point after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, the contribution of variable gene expression to viral control, and to relate it to genomic DNA polymorphism. RNA was extracted from purified CD4+ T-cells from 137 HIV-1 seroconverters, 16 elite controllers, and 3 healthy blood donors. Expression levels of more than 48,000 mRNA transcripts were assessed by the Human-6 v3 Expression BeadChips (Illumina). Genome-wide SNP data was generated from genomic DNA using the HumanHap550 Genotyping BeadChip (Illumina). We observed two distinct profiles with 260 genes differentially expressed depending on HIV-1 viral load. There was significant upregulation of expression of interferon stimulated genes with increasing viral load, including genes of the intrinsic antiretroviral defense. Upon successful antiretroviral treatment, the transcriptome profile of previously viremic individuals reverted to a pattern comparable to that of elite controllers and of uninfected individuals. Genome-wide evaluation of cis-acting SNPs identified genetic variants modulating expression of 190 genes. Those were compared to the genes whose expression was found associated with viral load: expression of one interferon stimulated gene, OAS1, was found to be regulated by a SNP (rs3177979, p=4.9E-12); however, we could not detect an independent association of the SNP with viral set point. Thus, this study represents the first attempt to integrate genome-wide SNP signals with genome-wide expression profiles in the search for biological correlates of HIV-1 control. It underscores the paradox of the association between increasing levels of viral load and greater expression of antiviral defense pathways. It also shows that elite controllers do not have a distinctive mRNA expression pattern in CD4+ T cells. Changes in RNA expression reflect responses to viral replication rather than a mechanism that might explain viral control

Hypothesis

Experimental Design

Total RNA from 202 samples obtained from CD4 T cells from HIV infected individuals to identify associations between variation in gene expression viral set point. Samples belong to different groups as follows (Paired Untreated/treated samples: 38/38, only untreated samples: 89, successfully treated samples: 29. Eight samples from 3 healthy blood donors in replicates.

Experimental Variables

Controls

Methods

Additional Information

Expected Samples:

202 Samples Loaded: 202

Species

Human (Homo sapiens)

Sample Source

CD4 T cells

Disease

HIV

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	!Sample Title	treatment	source	group	Cell type
GSM455579	CD4_Untreated 3078	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells
GSM455580	CD4_succesfully treated paired 3478	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells
GSM455581	CD4_Untreated paired NT3478	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells
GSM455582	CD4_succesfully treated 3487	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells
GSM455583	CD4_succesfully treated 3862	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells

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File
sampleset4000011_sampleannotations.csv Sample Set Spreadsheet
sampleset4000011_sampleannotations.csv Sample Set Spreadsheet

Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID	!Sample Title	Treatment	Source	Group	Cell type	Disease status	Viral load set point (log10)
GSM455579	CD4_Untreated 3078	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	1.96
GSM455580	CD4_succesfully treated paired 3478	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455581	CD4_Untreated paired NT3478	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.20
GSM455582	CD4_succesfully treated 3487	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455583	CD4_succesfully treated 3862	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455584	CD4_Untreated 3993	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.00
GSM455585	CD4_succesfully treated paired 5481	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455586	CD4_Untreated paired NT5481	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.06
GSM455587	CD4_Untreated 5486	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.72
GSM455588	CD4_Untreated 5488	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.09
GSM455589	CD4_Untreated NT5494	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.08
GSM455590	CD4_Untreated NT5505	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.30
GSM455591	CD4_Untreated 5521	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.06
GSM455592	CD4_succesfully treated paired 5538	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455593	CD4_Untreated paired NT5538	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.55
GSM455594	CD4_succesfully treated 5567	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455595	CD4_Untreated 5609	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.40
GSM455596	CD4_succesfully treated 3073	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455597	CD4_Untreated 3724	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.60
GSM455598	CD4_succesfully treated paired 5554	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455599	CD4_Untreated paired NT5554	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.29
GSM455600	CD4_Untreated 3011	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.51
GSM455601	CD4_Untreated 3013	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.59
GSM455602	CD4_Untreated 3130	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.11
GSM455603	CD4_Untreated 3131	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.44
GSM455604	CD4_Untreated 3336	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.60
GSM455605	CD4_Untreated 3422	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.85
GSM455606	CD4_Untreated 3517	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.40
GSM455607	CD4_Untreated 3535	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.14
GSM455608	CD4_Untreated 3539	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.37
GSM455609	CD4_Untreated 3595	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.75
GSM455611	CD4_Untreated 3713	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	0.90
GSM455612	CD4_Untreated 3907	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.67
GSM455613	CD4_Untreated 3929	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.02
GSM455614	CD4_Untreated 3984	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.60
GSM455615	CD4_Untreated 5076	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.15
GSM455616	CD4_Untreated 5627	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.02
GSM455617	CD4_succesfully treated 5633	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455618	CD4_succesfully treated 5637	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455619	CD4_Untreated 5640	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.69
GSM455620	CD4_Untreated 5641	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.70
GSM455621	CD4_Untreated 5645	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.98
GSM455622	CD4_Untreated 5646	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.44
GSM455623	CD4_Untreated 5647	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.49
GSM455624	CD4_succesfully treated paired 5649	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455625	CD4_Untreated paired NT5649	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.69
GSM455626	CD4_Untreated paired NT5650	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.50
GSM455627	CD4_succesfully treated paired 5650	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455628	CD4_succesfully treated 5652	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455629	CD4_succesfully treated 5659	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455630	CD4_Untreated 5662	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.06
GSM455631	CD4_Untreated NT5663	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.31
GSM455632	CD4_Untreated 5665	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.05
GSM455633	CD4_Untreated 5666	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.59
GSM455634	CD4_Untreated 5668	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.63
GSM455635	CD4_Untreated 5669	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.55
GSM455636	CD4_Untreated 5671	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.39
GSM455637	CD4_succesfully treated 5672	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455638	CD4_succesfully treated paired 5674	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455639	CD4_Untreated paired NT5674	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.76
GSM455640	CD4_Untreated 5675	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.59
GSM455641	CD4_Untreated 5676	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.06
GSM455642	CD4_Untreated 5677	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.03
GSM455643	CD4_Untreated 5679	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.86
GSM455644	CD4_Untreated 5681	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	0.56
GSM455645	CD4_Untreated 5682	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.19
GSM455646	CD4_Untreated 5683	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.01
GSM455647	CD4_Untreated 5684	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.78
GSM455648	CD4_succesfully treated 5685	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455649	CD4_Untreated 5686	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.08
GSM455650	CD4_Untreated 5687	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.69
GSM455651	CD4_Untreated 5688	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.95
GSM455652	CD4_Untreated 5690	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.75
GSM455653	CD4_succesfully treated 5699	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455654	CD4_Untreated 5696	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.32
GSM455655	CD4_Untreated NT5701	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.06
GSM455656	CD4_succesfully treated 5703	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455657	CD4_succesfully treated 5704	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455658	CD4_Untreated NT3083	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.96
GSM455659	CD4_succesfully treated 3085	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455660	CD4_Untreated NT3100	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.04
GSM455661	CD4_succesfully treated 3149	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455662	CD4_succesfully treated 3152	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455663	CD4_succesfully treated paired 3195	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455664	CD4_Untreated paired NT3195	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.04
GSM455665	CD4_Untreated NT3200	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.23
GSM455666	CD4_succesfully treated paired 3216	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455667	CD4_Untreated paired NT3216	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.72
GSM455668	CD4_succesfully treated paired 3218	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455669	CD4_Untreated paired NT3218	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.50
GSM455670	CD4_succesfully treated paired 3226	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455671	CD4_Untreated paired NT3226	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.02
GSM455672	CD4_succesfully treated 3307	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455673	CD4_Untreated NT3423	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.54
GSM455674	CD4_succesfully treated 3477	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455675	CD4_Untreated NT3579	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.95
GSM455676	CD4_succesfully treated paired 3639	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455677	CD4_Untreated paired NT3639	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.25
GSM455678	CD4_succesfully treated paired 3640	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455679	CD4_Untreated paired NT3640	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.06
GSM455680	CD4_Untreated NT3641	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.18
GSM455681	CD4_succesfully treated paired 3698	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455682	CD4_Untreated paired NT3698	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.96
GSM455683	CD4_succesfully treated 3937	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455684	CD4_succesfully treated paired 3999	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455685	CD4_Untreated paired NT3999	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.34
GSM455686	CD4_Untreated NT5002	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.52
GSM455687	CD4_succesfully treated 5136	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455688	CD4_succesfully treated 5140	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455689	CD4_succesfully treated paired 5470	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455690	CD4_Untreated paired NT5470	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.78
GSM455691	CD4_Untreated 5471	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.98
GSM455692	CD4_succesfully treated paired 5474	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455693	CD4_Untreated paired NT5474	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.21
GSM455694	CD4_Untreated 5475	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.90
GSM455695	CD4_Untreated NT5478	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.08
GSM455696	CD4_succesfully treated 5483	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455697	CD4_Untreated 5487	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.28
GSM455698	CD4_succesfully treated 5490	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455699	CD4_succesfully treated paired 5491	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455700	CD4_Untreated paired NT5491	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.84
GSM455701	CD4_Untreated 5492	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.37
GSM455702	CD4_Untreated 5493	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.78
GSM455703	CD4_succesfully treated 5496	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455704	CD4_succesfully treated paired 5497	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455705	CD4_Untreated paired NT5497	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.87
GSM455706	CD4_succesfully treated paired 5498	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455707	CD4_Untreated paired NT5498	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.00
GSM455708	CD4_succesfully treated 5499	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455709	CD4_succesfully treated paired 5500	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455710	CD4_Untreated paired NT5500	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.49
GSM455711	CD4_Untreated 5501	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.46
GSM455712	CD4_succesfully treated paired 5502	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455713	CD4_Untreated paired NT5502	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.90
GSM455714	CD4_Untreated 5503	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.87
GSM455715	CD4_Untreated 5504	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.91
GSM455716	CD4_Untreated 5507	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.12
GSM455717	CD4_succesfully treated paired 5508	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455718	CD4_Untreated paired NT5508	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.50
GSM455719	CD4_Untreated 5510	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.62
GSM455720	CD4_Untreated NT5513	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.31
GSM455721	CD4_Untreated 5517	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.15
GSM455722	CD4_succesfully treated paired 5518	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455723	CD4_Untreated paired NT5518	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.34
GSM455724	CD4_Untreated NT5519	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.85
GSM455725	CD4_succesfully treated 5520	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455726	CD4_succesfully treated paired 5522	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455727	CD4_Untreated paired NT5522	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.08
GSM455728	CD4_Untreated NT5528	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.70
GSM455729	CD4_succesfully treated paired 5530	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455730	CD4_Untreated paired NT5530	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.93
GSM455731	CD4_Untreated 5532	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.64
GSM455732	CD4_Untreated 5533	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.28
GSM455733	CD4_succesfully treated paired 5534	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455734	CD4_Untreated paired NT5534	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.62
GSM455735	CD4_succesfully treated paired 5535	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455736	CD4_Untreated paired NT5535	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.69
GSM455737	CD4_Untreated 5539	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.62
GSM455738	CD4_Untreated 5542	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.50
GSM455739	CD4_succesfully treated paired 5543	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455740	CD4_Untreated paired NT5543	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.02
GSM455741	CD4_Untreated 5544	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Elite controller	1.76
GSM455742	CD4_Untreated NT5545	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.05
GSM455743	CD4_succesfully treated paired 5550	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455744	CD4_Untreated paired NT5550	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.72
GSM455745	CD4_Untreated 5555	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.64
GSM455746	CD4_Untreated 5556	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.54
GSM455747	CD4_Untreated NT5557	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.54
GSM455748	CD4_succesfully treated paired 5558	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455749	CD4_Untreated paired NT5558	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.61
GSM455750	CD4_succesfully treated paired 5560	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455751	CD4_Untreated paired NT5560	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.58
GSM455752	CD4_succesfully treated paired 5562	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455753	CD4_Untreated paired NT5562	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.38
GSM455754	CD4_Untreated 5563	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.60
GSM455755	CD4_succesfully treated paired 5564	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455756	CD4_Untreated paired NT5564	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.57
GSM455757	CD4_succesfully treated paired 5565	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455758	CD4_Untreated paired NT5565	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.84
GSM455759	CD4_Untreated 5569	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.23
GSM455760	CD4_Untreated 5586	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.18
GSM455761	CD4_succesfully treated paired 5613	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455762	CD4_Untreated paired NT5613	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.36
GSM455763	CD4_succesfully treated paired 5615	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455764	CD4_Untreated paired NT5615	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	2.80
GSM455765	CD4_Untreated 5616	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.38
GSM455766	CD4_succesfully treated 5619	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455767	CD4_Untreated NT5620	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.34
GSM455768	CD4_succesfully treated 5622	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455769	CD4_Untreated 5623	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	3.99
GSM455770	CD4_succesfully treated paired 5626	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455771	CD4_Untreated paired NT5626	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	5.51
GSM455772	CD4_succesfully treated 5628	Succesfully treated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	0.00
GSM455773	CD4_Untreated NT5629	Untreated	frozen PBMC	HIV infected individuals	CD4 T cells	Progressor	4.09
GSM455774	CD4_uninfected sample control_rep1 pull 3_ATE 048	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455775	CD4_uninfected sample control_rep2 pull 3_ATE 051	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455776	CD4_uninfected sample control_rep3 pull 3 ATE 057	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455777	CD4_uninfected sample control_rep1 pull 1 ATE 063	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455778	CD4_uninfected sample control_rep2 pull 1_ATE 078	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455779	CD4_uninfected sample control_rep1 pull 2 ATE 105	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455780	CD4_uninfected sample control_rep2 pull 2_ATE 108	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00
GSM455781	CD4_uninfected sample control_rep3 pull 2_ATE 196	Uninfected	frozen PBMC	Healthy blood donors	CD4 T cells	Uninfected	0.00

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SIDRA